NFL Opening Night: Rams vs. Bills Betting Guide

KANSAS CITY, MO – JANUARY 23: Buffalo Bills quarterback Josh Allen (17) in the field prior to the AFC Divisional Round Playoff game against the Kansas City Chiefs on January 23, 2022 at Arrowhead Stadium in Kansas City, Missouri. (Photo by William Purnell/Icon Sportswire)

We finally got there! The 2022 NFL season begins tomorrow night, and SGPN is here with your opening night betting guide. The Los Angeles Rams host the Buffalo Bills in what many expect to be a high-scoring shootout. We’ve been patiently waiting all offseason for that big night, and we’ve got the best picks to net you some cash before kickoff on Sunday. We’ll go over Money Line, ATS, and Game Total Picks as well as some accessory options for players.

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NFL Opening Night: Rams vs. Bills Betting Guide

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I expect a tight game to kick off the NFL campaign. We have a tight game between two teams that can both score at will and play defensively. While the Bills’ offense feels improved with the expected advancement of Gabe Davis and the addition of james cook, they will be without Tre’davious White to start the season. His absence will be felt on opening night.

The Rams defense has playmakers at every level, including Aaron Donald, Bobby Wagnerand Jalen Ramsey. Their offense may not be as good as the Bills as a whole, but it’s close enough to win this game. The Rams will be without Van Jeffersonso expect full Cooper Kupp experience combined with the emergence of Allen Robinson.

Neither team has an advantage to direct the ball. We will see a combination of running backs used by both teams. Both teams play the run very well, so it will be interesting to see which running back ends up with the better stats; they will be an x ​​factor in this game. The course of the game should encourage more passes from both teams.

Josh Allen is the best QB in the league, but I roll with the home team and their advantage on defense. This group will make it difficult for the Bills to close this game. I trust the Rams offense to score more than 30 more points than I trust the Bills to reach that threshold. Rams are +115 to WynnBet; I love me some Home Dogs!

Los Angeles Rams ML +115


Against the spread

The Rams are underdogs, so if you’re not sold on the outright win, you can take advantage of the -110 discount for them to cover +2.5 points. I take the Rams to win the game, but I believe this game comes down to the final procession; Yes, it’s true; we get all the fireworks on opening night! I would recommend buying the number up to three or even 3.5, yes you will lose value, but I see this one going down the wire.

The Bills’ defense is very talented even without White; they could arrive late and spoil the Rams’ home opener after the Super Bowl. If the Rams were to lose, I would still trust them to keep him close enough to cover from three to 3.5 points.

You can pair this safer pick with the total or a player accessory you like to recoup some of that value you expected. You can make the Rams cover +2.5 to Wynnbetbut heed my advice and redeem half or the whole point.

Los Angeles Rams +3

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Game total

The total of the game at WynnBet is 52 points. Of course, this number is always subject to change depending on public market demand. I predict a score of 31-27 in favor of the Rams. This is a touchdown over the expected score. I predict the teams will start slowly, but we will see a flurry of goals to finish half-time and until the end of the match.

Both teams will play chicken with the run game and take some practice shots on the field to start the match. Once both teams realize it’s not there on the field, the flow of play will shift to more passing and points will come in more quickly in the middle and end of the game. In the worst case, we hit that bet with a winning touchdown from either team.

The total for the first half is 25.5 to WynnBet; despite even a slow start, I can easily see this game tied 14-14 or 17-14 at halftime. I will take over for the first half and the match itself.

Over 52 games in total / Over 25.5 in total in first half


Player Accessories

Tyler Higbee Anytime hit +195

I love that pick, and it’s a total nod to the Bills defense. They’ll cause the Rams problems at some point, and I bet Higbee can play opossum and punch a deep cover game or end up as an ultimate target in the red zone. There should be a few more targets to grab with Van Jefferson offside. I’m willing to take a chance and say Higbee will be the first touchdown scorer as well. You can get +1600 for this choice at WynnBet.

Josh Allen Over 37.5 rushing yards -125

The Bills allowed the second fewest sacks last season. Shout out to their offensive line, but let’s be honest; we all know Allen has wheels and can always extend games. His rushing advantage will be needed in this one as the Rams clog the early running lanes. Hopefully Allen will be needed to extend workouts with his legs, as the Rams secondary should cover the Bills with some consistency.

Gabriel Davis Over 4.5 catches +118

Gabe Davis start next Stefan Diggs but has much more favorable coverage matches. Davis could be Allen’s early favorite as Jalen Ramsey will follow Stefon Diggs. That’s not to say Diggs won’t produce in this match, but it could take him a while to consistently break cover. Davis is in a great position to produce at the start of the year as the Bills find their identity on the court; that number is too low given the game’s total, its A1 quarterback, and the upside coverage.

Matthew Stafford Over 273.5 passing yards -125

The Rams offense will also have its issues establishing the run, and for that, I like Matthew by Stafford accessories for opening night. I also mentioned the absence of Tre’davious White. There is a clear path for 300+ passing yards in this game for Stafford. I bet the Rams play from behind but keep the game close enough for a game-winning drive to end the game or with minimal time on the clock. Stafford has big deep threats in Allen Robinson and Cooper Kupp. All three will be needed to beat the Bills on opening night.

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